The nicotinic receptor proteins exist in human prenatal, brain beginning at 4 to 5 weeks of gestation, if a substance (like nicotine) is presented it would affect the function of the receptors in modulating dendritic outgrowth, establishmentof neuronal connections, and synaptogenesis (The formation of synapses between neurons as the axons and dendrites grow) during development.
These would lead to discoordination oftarget cell replication and differentiation. Prenatal nicotine exposure has been associated with region-specific differences (cortical greater than subcotical) in expression of the nicotinic receptor subunits nicotine stimulated catecholamine
release occurred in parallel with the ontogeny of nicotinic cholinergic receptors in the midbrain, brainstem, and forebrain during a period that corresponds to the last trimester of human pregnancy.
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